摘要
目的:探讨氟西汀合并小剂量氯氮平治疗抑郁症的疗效。方法:将80例抑郁症患者随机分成氟西汀组(单用组)和氟西汀合并小剂量氯氮平组(合用组)。共观察6周。于治疗前、后1、2、4、6周末采用汉密尔顿抑郁量表(HAMD),不良反应量表(TESS)评定疗效及不良反应。结果:治疗每6周末氟西汀合并小剂量氯氮平组疗效显著。合用组与单用组的有效率分别为85.2%和61%,有显著差异(X2=4.031,P<0.05)使用组在1周内起效,单用组在两周末起效。两组治疗后1、2、4周HAMD评分显著性差异(P<0.05);TESS评分无明显差异(P>0.05)。结论:氟西汀合并小剂量氯氮平治疗抑郁症起效快,睡眠明显改善。克服了抗抑郁药起效慢的特点。
Objective To study the clinical effect of fluoxetine with small doses clozapine in the treatment of depressearch（fluoxetine and clozapine）group and control（fluox-etine） group for the treatment of 6 weeks The efficacy and side effects were evaluated with HAMD and TESS. Results The treatment of fluoxetine with clozapine was effec- tive and the tolerance was better after 6- week treatment. There were significant differences in HAMD of first week, second week ,forth week after treatment between two groups. But there was no difference in TESS. Conclusion Fluoxetine with small doses clozapine could improve the efficacy compared with fluoxetine in treating depression.
关键词
氟西汀
小剂量氯氮平
抑郁症
fluoxetine Small doses clozapine Depression
