摘要
目的:了解海洛因依赖人群出现与帕金森病类似的症状体征的情况。方法:采用帕金森病统一评分量表(United Parkinson’s Disease Rate Scale,UPDRS量表)对121名海洛因依赖者及31名年龄、性别、文化程度相匹配的对照组志愿者进行评分,其数据作统计学分析。结果:海洛因依赖人群的UPDRS分值显著高于对照组志愿者,静脉吸毒、复吸、长期吸毒均能提高UPDRS分值,对于震颤、动作缓慢、姿势不稳、步态异常等症状,海洛因依赖者的出现率明显高于正常对照组。结论:海洛因依赖可导致类似于帕金森病的症状体征出现,其原因可能是由于脑内黑质纹状体多巴胺系统受损。
Objective：To understand the manifestation of Parkinson＇ s Diseaselike symptoms and signs among heroin dependent patients. Methods：121 heroin dependent patients and 31 age -, sex - and educational - level matched non - drug - abusing control volunteers were assessed using the United Parkinson＇ s Disease Rate Scale （UPDRS）. The data were statistically analysed. Results ： Heroin dependent patients showed significantly higher UPDRS score than the control subjects. And intravenous （Ⅳ） administration of heroin, a relapse history of heroin and longer period of heroin abuse, seemed to contribute to higher UPDRS score. Motor disorder （tremor, bradykinesia, postural instability, gait abnormity, etc ） was more predominant in heroin dependent patients than in the control subjects. Conclusions：Heroin dependence can induce some symptoms and signs like PD. It can be postulated that heroin dependence may have neuronal toxic impact on the striatal dopamine systems.
出处
《中国药物依赖性杂志》
CAS
CSCD
2008年第1期44-48,共5页
Chinese Journal of Drug Dependence
基金
国家自然科学基金重大国际合作项目(30420120048)
国家自然科学基金项目(30670598
30200068)
