摘要
利用壳聚糖和琥珀酸酐反应合成了N-琥珀酰壳聚糖,1H NMR分析表明通过反应可在壳聚糖的侧氨基引入亲水性的羧基,增加琥珀酸酐/氨基的摩尔投料比或者选择分子质量较小的壳聚糖,有利于提高N-琥珀酰壳聚糖的琥珀酰化度.等电点分析结果表明,壳聚糖分子质量越小,N-琥珀酰壳聚糖的等电点pI值越低.溶解度分析结果表明,N-琥珀酰壳聚糖的亲水性得到明显改善,在中性条件下表现出微弱的溶解性,但在酸性和碱性条件下均表现出良好的溶解性,此性质对其在生物医学和药物载体方面的应用具有重要的意义.
N-succinyl-chitosan（Suc-Chi） was synthesized via reactions with chitosan and succinic anhydride in this work. The analysis of ^1H NMR showed that the succinyl group was successfully conjugated to the amino group of chitosan molecule, and the degree of substitution （DS） of Suc-Chi values increased with increasing succinic anhydride/amino mole ratio or reducing the molecular weight of chitosan. A lower isoelectric point （pI） of Suc-Chi was obtained while using a chitosan with a lower molecular weight. The results of UV-spectrophotometric analysis indicated that Suc-Chi, exhibiting a better soluble property than chitosan, showed a low solubility at neutral condition, but easily disolved in both acid and basic solutions. The knowledges of physical-chemical properties for Suc-Chi are valuable for applied purposes in both biomedical and pharmaceutical sciences.
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
北大核心
2008年第1期77-80,共4页
Journal of Jinan University(Natural Science & Medicine Edition)
基金
广东省自然科学基金资助项目(06300590)
国家自然科学基金资助项目(30500128)
关键词
N-琥珀酰壳聚糖
合成
物理化学性质
N-succinyl-chitosan
synthesis
physical-chemical properties
