摘要
背景:研究表明,健康男女骨密度峰值出现在大约20～40岁之间,进入中老年后骨量逐渐下降,从而导致骨质疏松症。目的:分析北京市东城区2个居委会289名健康中老年人骨密度变化及骨质疏松患病特征。设计:横断面调查。单位:卫生部北京医院北京老年医学研究所。对象:于1998-06/09采用整群随机方法选择北京市东城区2个居委会的289名45岁以上健康居民,男136名,女153名,年龄45～85岁。排除标准:①肝肾功能异常。②有影响骨代谢的各种因素(如:各种急慢性疾病;长期服用激素、钙剂等药物史;体脂指数小于19kg/m2或大于28kg/m2;长期卧床3个月以上;特殊职业人群)。所有受试对象均对检测项目知情同意。方法:采用美国Lunar公司的双能X线骨密度仪对所有受试对象进行骨密度测定,部位为左侧股骨近端(股骨颈,大转子,Ward’s三角区),腰椎2～4前后位。按世界卫生组织提出的骨质疏松症的诊断标准及本攻关项目获得的骨峰值确定各个部位骨质疏松症的诊断标准,股骨径:男性0.665g/cm2,女性0.677g/cm2;大转子:男性0.598g/cm2,女性0.506g/cm2;Ward’s三角区:男性0.492g/cm2,女性0.514g/cm2;腰椎2～4:男性0.760g/cm2,女性0.835g/cm2。同时参考"九五"攻关课题获得的骨峰值计算骨量丢失率和骨质疏松的患病率。主要观察指标:不同性别不同部位受试对象骨密度、骨量丢失率及骨质疏松患病率。结果:纳入调查对象289名均进入结果分析。①男性的骨密度随年龄增高的趋势不显著,女性骨密度降低以及骨量丢失均十分突出,且以55岁以后更加明显。②按部位分析骨量累积丢失率,男女均依次为Ward’s三角区>股骨径>大粗隆>腰椎2～4。③骨质疏松患病率随年龄明显升高,女性显著高于男性,差异有统计学意义(P<0.01)。骨质疏松发生以股骨径最高,其次是Ward’s三角区和腰椎2～4。结论:女性性别和年龄增加,尤其是绝�
BACKGROUND： Some researches demonstrate that bone mineral density of healthy males and females whose ages range from 20 to 40 years reaches the peak. With the age growing, bone mineral density decreases gradually so as to cause osteoporosis. OBJECTIVE： To analyze changes of bone mineral density and characteristics of osteoporosis in 289 healthy middle and old aged people in two communities, Dongcheng district, Beijing. DESIGN： Cross-sectional study. SETTING： Beijing Institute of Geriatrics, Beijing Hospital, Ministry of Health. PARTICIPANTS： A total of 289 healthy residents over 45 years old were randomly selected from two communities, Dongcheng district, Beijing from June to September 1998. There were 136 males and 153 females, and their ages ranged from 45 to 85 years. Exclusion criteria： （1）Hepatic and renal disfunction; （2） effects of various factors on bone metabolism （various acute and chronic diseases; histories of long-term administration of hormone and calcium preparation; 19 kg/m2 〉 index of body mass 〉 28 kg/m2; long-term bed over three months; unusual occupation）. All subjects provided the confirmed consent. METHODS： Dual-energy X-ray bone density meter （Lunar Company, USA） was used to measure bone mineral density of all subjects at proximal end of left femur （neck of femur, great troch, Ward＇s triangle） and antero-posterior position of lumbar spine （L2-4）. Diagnostic criteria of osteoporosis set by WHO and peak bone value acquired from a tackle key program were used to determine diagnostic standards of osteoporosis at various sites. The diagnostic standards were detailed as follows： neck of femur： 0.665 g/cm2 of males and 0.677 g/cm2 of females; great troch： 0.598 g/cm2 of males and 0.506 g/cm2 of females; Ward＇s triangle： 0.492 g/cm2 of males and 0.514 g/cm2 of females; L2_4：0.760 g/cm2 of males and 0.835 g/cm2 of females. Meanwhile, peak bone value acquired by Key Program During the Ninth Five-Year Plan Period was used to calculate bone minera
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2008年第2期397-400,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
国家"九五"科技攻关计划资助项目(96-906-05-01)
国家"九五"攻关"社区主要老年疾病综合防治试点研究"项目~~
