摘要
目的研究脑梗死患者血清中肝细胞生长因子(hepatocyte growth factor,HGF)的动态变化、低分子肝素对其影响及临床意义。方法用双抗体夹心ELISA法测定脑梗死患者发病后24h^21d血清HGF含量的动态变化及皮下注射低分子肝素对其变化的影响。结果脑梗死患者与对照组比较在病程各时间点上血清HGF浓度均增高;梗死灶大者HGF水平高,皮下注射低分子肝素可升高血清HGF浓度。结论脑缺血后可上调HGF在大脑的表达,HGF可能参与缺血性脑损伤的病理发展及修复过程;血清HGF含量有可能成为诊断脑缺血的标志物及反映脑缺血程度的一个敏感指标;皮下注射低分子肝素可能存在抗血栓以外的其他作用。
Objective To investigate the changes and clinical values of HGF in cerebral ischemic patients and the influence of low molecular heparin on it. Methods Serum HGF levels of cerebral infarction patients were serially determined by ELISA. Results The levels of HGF in cerebral infarction patients were much higher than that in control group with a highly significant difference （P〈0. 01）. The cerebral infarction patients with larger lesions had higher HGF levels. Administration of low molecular heparin caused increase in serum HGF. Conclusions HGF expression is up-regulated by ischemia. HGF may be involved in the pathological and recovery process of ischemic stroke. Determination of serum HGF may serve as a sensitive monitor of cerebral ischemic degree.
出处
《卒中与神经疾病》
2008年第1期3-5,共3页
Stroke and Nervous Diseases
关键词
脑缺血
肝细胞生长因子
低分子肝素
Cerebral ischemia Hepatocyte growth factor Low molecular heparin
