摘要
目的研究月见草油对十二指肠溃疡（ＤＵ）的治疗作用．方法选经内镜确诊为ＤＵ的住院患者１２０例，随机分为治疗组（ｎ＝６０）和对照组（ｎ＝６０）．治疗组服用月见草油１５ｇ，４次／ｄ，对照组服用西味替丁２００ｍｇ，４次／ｄ，两组均为４周１疗程．治疗前及治疗４周后各做胃镜１次，观察溃疡的愈合情况，同时，治疗前及治疗４周后用放免法分别测定血浆内的ＰＧＥ２含量．结果治疗组与对照组患者的消化道症状均较服药前明显减轻（Ｐ＜００１），两组间无显著性差异（Ｐ＞００５）．４周溃疡愈合率和有效率，治疗组为７６６％和８６６％，对照组分别为７００％和８３３％，两组间无显著性差异（Ｐ＞００５），对照组于治疗前后血浆ＰＧＥ２水平无显著性差异，而治疗组于治疗前后的血浆ＰＧＥ２水平却有显著性差异（９４５ｎｇ／Ｌ±３７ｎｇ／Ｌ→１７２３ｎｇ／Ｌ±５７ｎｇ／Ｌ，Ｐ＜００５）．结论月见草对ＤＵ的近期疗效较好，可用于治疗ＤＵ．
AIM To study the effect of Oenothera biennis L. on duodenal ulcer healing. METHODS One hundred and twenty cases of inpatients with active duodenal ulcer (DU) diagnosed by endoscopy were divided randomly into therapy group ( n =60) and control group ( n =60). Patients in therapy group took Oenothera biennis L. 1 5g, 4 times a day; while the control group took cimetidine 200mg, 4 times a day, for 4 weeks. Endoscopic examinations were made before and at the end of treatment, and the plasma PGE 2 levels before and at the end of treatment were also measured with RIA. RESULTS The digestive symptoms of the patients in both groups were improved after treatment ( P <0 01), with no difference between the two groups ( P >0 05). The cure rate of DU in Oenothera biennis L. group was 76 6%, the total effective rate was 86 6%, while that in cimetidine group was 70 0% and 83 3% respectively with no significant difference between the two groups ( P >0 05). There was no difference in the plasma PGE 2 levels of the control group before and after treatment ( P >0 05), but the plasma PGE 2 levels of the therapy group were more markedly increased after treatment than before treatment (94 5ng/L±3 7ng/L to 172 3ng/L±5 7ng/L, P <0 05). CONCLUSION The therapeutic effect of Oenothera biennis L. in DU is satisfactory. It can be used as the substitute drug to treat DU.
关键词
十二指肠溃疡
药物疗法
月见草油
Cenothera erythrosepala/therapeutic use\ \ Duodenal ulcer/drug therapy
