摘要
目的探讨急诊监护室(EICU)危重病患者血清硫化氢(H2S)浓度改变与急性生理学及慢性健康状况评分Ⅲ(APACHEⅢ)及预后的关系。方法采用分光光度法检测72例入住EICU的危重病患者及12例健康体检者的血清H2S浓度,并对危重病患者进行APACHEⅢ评分;分析血清H2S浓度与APACHEⅢ评分及死亡率的关系。结果72例患者血清H2S浓度为(45.6±17.2)μmol/L,存活组血清H2S浓度(41.1±14.7)μmol/L,死亡组血清H2S浓度(62.8±15.5)μmol/L,两组比较差异有统计学意义(P<0.01);72例患者APACHEⅢ评分(43.6±26.0)分,存活组APACHEⅢ评分(37.7±22.2)分,死亡组APACHEⅢ评分(65.0±29.6)分,两组比较差异有统计学意义(P<0.01)。血清H2S浓度与APACHEⅢ评分呈正相关(r=0.7422,P<0.01),随各组血清H2S浓度增高,APACHEⅢ评分值亦增高(F=33.69,P<0.001),各组死亡率也随之增高(χ2=24.48,P<0.01)。结论急诊危重病患者血清H2S浓度较健康者明显增高,对判断病情及预后有一定的作用。
Objective To explore the relationship between acute physiology and chronic health evaluation Ⅲ（APACHEⅢ）scores and serum hydrogen sulfide（H2S）concentration,prognosis of patients admitted to Emergency Intensive Care Unit（EICU）.Methods The APACHEⅢ scores of the patients were assessed.The serum H2S levels were measured in 72 cases and 12 controls by spectrophotometry,and the relationship between APACHEⅢ scores and serum H2S concentration,prognosis were analyzed.Results The average APACHEⅢ score of the 72 cases was（43.6±26.0）.The APACHE Ⅲ score（37.7±22.2）in the survival group was significantly lower than that（65.0±29.6）in the dead group,P〈0.01.The average serum H2S concentration of the 72 cases was（45.6±17.2）μmol/L.The H2S concentration in the survival group was（41.1±14.7）μmol/L,which was significantly lower than（62.8±15.5）μmol/L in the dead group,P〈0.01.The higher the APACHE Ⅲ scores was,the higher the serum H2S concentration was（F=33.69,P〈0.001）and the mortality（χ2= 24.48,P〈0.01）.Conclusion Serum H2S levels of patients in EICU were obviously higher than those of the healthy people,which plays an important role in judging the conditions and prognosis of patients admitted to EICU.
出处
《中国急救医学》
CAS
CSCD
北大核心
2008年第1期15-17,共3页
Chinese Journal of Critical Care Medicine
关键词
急性生理学及慢性健康状况评分Ⅲ
硫化氢
急诊危重病
预后
Acute physiology and chronic health evaluation Ⅲ（APACHEⅢ）
Hydrogen sulfide
Emergency intensive care unit
Prognosis
