摘要
目的比较中、老年代谢综合征(MS)患者的临床特点。方法收集1996～2006年在解放军总医院门诊查体且符合中国人MS诊断标准(CDS)的947例中、老年患者的临床资料。其中老年人679例,中年人268例。分析中、老年患者MS各组分的差异,以及各组分的相关因素等。结果947例患者中,男性582例(老年423例,中年159例),女性365例(老年256例,中年109例)。老年男性患者的年龄大于老年女性(81.5±6.5vs74.5±8.8岁,P<0.01),老年男性的体重指数(BMI)高于中年男性(27.14±2.51vs25.98±2.38,P<0.01)。老年患者的空腹、餐后血糖和收缩压均高于同性别的中年患者,而舒张压无显著差异。中年男性的甘油三酯高于老年男性。中年女性的高密度脂蛋白胆固醇高于男性。多元回归分析显示,男女患者空腹血糖均与餐后2h血糖有相关性(男性R2=0.463,P<0.05;女性R2=0.613,P<0.05)。餐后2h血糖与年龄存在相关性(男性,R2=0.522,P<0.01;女性R2=0.716,P<0.05)。收缩压与多种指标均有相关性,男性患者收缩压与年龄(R2=0.396,P<0.01)和舒张压(R2=0.535,P<0.05)均有相关性;女性患者的收缩压与BMI(R2=0.557,P<0.05)、舒张压(R2=0.434,P<0.05)、餐后2h血糖(R2=0.434,P<0.01)及空腹血糖(R2=0.473,P<0.05)均有相关性。Logistic回归分析示年龄(OR=2.1,95%CI:1.3～2.7)、空腹血糖(OR=1.7,95%CI:1.2～3.1)和收缩压(OR=1.4,95%CI:1.2～2.9)是预测代谢综合征组分含量的影响因素。结论中老年代谢综合征患者的代谢指标有差异,年龄、空腹血糖和收缩压可作为代谢综合征的筛选指标。
Objective To investigate the different clinical features of metabolic syndrome（MS）in middle-aged and elderly patients.Methods Data were collected from 947 MS patients,for whom the diagnosis was established based on the Chinese criteria.Of them,679 were elderly people and 268 were in middle-age.Laboratory examination and medical history were analyzed.BMI,blood glucose,blood pressure（BP）and lipid profile were measured.Patients were divided into different groups according to age and sex.Results In the elderly group,the age of male and female patients was 81.5±6.5 and 74.5±8.8 years,respectively.BMI of elderly males were higher than that of middle-aged males（27.14±2.51 vs 25.98±2.38）.All the elderly patients had higher systolic BP,but lower triglyceride level than that of the middle aged patients.In middle-aged group,female patients had higher high-density lipoprotein.Fasting blood glucose level in all the investigated subjects was correlated with postprandial glucose（for male R^2=0.463,P〈0.05,for female R^2=0.613,P〈0.05）,while the postprandial glucose level was correlated with age（for male,R^2=0.522,P〈0.01,for female R^2=0.716,P〈0.05）.The systolic BP showed a positive correlation with various factors（in males,with age R^2=0.396,P〈0.01,with diastolic BP R^2=0.535,P〈0.05,in females,with BMI R^2=0.557,P〈0.05,with diastolic BP R^2=0.434,P〈0.05,with 2hPBG R^2=0.434,P〈0.01,with FPG R^2=0.473,P〈0.05）.Age（OR=2.1,95%CI：1.3-2.7）,fasting glucose（OR=1.7,95%CI：1.2-3.1）and systolic BP（OR=1.4,95%CI：1.2-2.9）were the predictive factors of other components of MS according to the Logistic regression analysis.Conclusion Aged and middle-aged patients with MS had different clinical features.Age,fasting glucose and systolic BP could be used as useful index for MS screening.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2007年第12期1254-1256,共3页
Medical Journal of Chinese People's Liberation Army
关键词
代谢综合征X
老年人
中年人
糖尿病
血压
metabolic syndrome X,aged,middle aged,diabetes mellitus,blood pressure
