摘要
评价骨质疏松症与维生素A之间的关系。北欧居民骨质疏松性骨折发病率很高,相关研究发现可能与当地地处高纬度,日光照射时间短造成皮肤1,25（OH）VitD3合成不足有关;另一项相关性研究发现北欧居民骨质疏松性骨折的发病与他们饮食摄入维生素A的量很高也有关。维生素A是普遍运用的维生素。研究显示维生素A过量和缺乏都会刺激和抑制骨的形成,这种影响可能会导致骨量丢失和骨折。人的一生中骨骼不断生长,在骨代谢的过程中有多种维生素参与,其中包括维生素A的参与。为了探讨维生素A与骨质疏松的关系,笔者通过检索相关文献并进行综述。大量研究显示：①维生素A摄入量少于1500μgRE/d而大于500μgRE/d时,对骨密度没有影响;②饮食摄入β-胡萝卜素与骨折风险没有关系;③短期给予大量维生素A在男性不会对骨代谢产生影响;④给予卵巢切除的大鼠大量维生素A,其骨质量明显减少。每天摄入500～1500μgRE维生素A时不会对骨密度及骨折风险产生影响,但是否对骨代谢产生决定性的影响还需要更进一步的研究来评价。
Evaluate the relationship between osteoporosis and vitamin A. A related study found that the Nordic residents have a higher incidence of osteoporotic fracture. Their dietary intake of vitamin A was unusually high. Vitamin A is a commonly used vitamin. Study shows excessive or insufficient intake of vitamin A stimulates bone resorption and inhibits bone formation, eventually leading to bone loss and fracture. In the course of bone metabolism, an increasing number of vitamins have participated, including of vitamin A. To inverstigate the relationship between vitamin A and osteoporosis, the review summarized the structures and function of vitamin A and their important function in osteoporosis. These studies have shown： 1. Excessive or insufficient intake of vitamin A is associated with lower bone mineral density and increased risk for osteoporosis fracture ; 2. The high serum β- carratene is not associated with osteoporosis;. 3. It is unlikely that short-term administration of a great quantity vitamin A would contribute to the development of osteoporosis; 4. Bone mass of ovariectomized rats that take in a great quantity of vitamin A will decrease. The analysis showes intake of doses from 500 μgRE/d to 1500 μgRE/d of vitamin A would not affect bone mineral density and bone fracture. However, whether or not it would affect bone metabolism needs further study.
出处
《中国骨质疏松杂志》
CAS
CSCD
2008年第2期134-137,共4页
Chinese Journal of Osteoporosis
