胃癌的反义基因治疗

Antisense gene therapy of stomach cancer

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摘要研究表明，胃癌的形成与人端粒酶、热休克蛋白70（HSP70）、细胞周期素D1（cyclinD1）、bcl-2在胃癌细胞中过表达密切相关。通过人端粒酶、HSP70、cyclinDI、bcl-2的反义基因可对其本身在胃癌细胞中的表达加以限制，以达到治疗胃癌的目的。 Researches indicate that stomach cancer formation has a close correlation with high expression of human telomerase,hot shock protein 70 （HSP70） ,cell cycle element D1 （cyclin DI ） and bcl-2 in the stomach cancer cells. The antisense genes of human telomerase,HSP70,cyclin DI and bcl-2 can limit their expressions in stomach cancer cells and can be used for stomach cancer therapy.

作者饶建锋(综述) 罗忠金(审校) 张吉翔(审校)

机构地区南昌大学第二附属医院消化内科

出处《国际肿瘤学杂志》 CAS 2008年第2期134-136,共3页 Journal of International Oncology

关键词胃肿瘤 DNA 反义基因疗法 Stomach neoplasms DNA,antisense Gene therapy

分类号 R735.2 [医药卫生—肿瘤]

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参考文献9

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胃癌的反义基因治疗

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