摘要
目的观察瑞波西汀合并氯氮平对伴有阴性症状的精神分裂症患者生活质量的疗效及副反应。方法采用随机法,将114例慢性精神分裂症患者分为研究组(瑞波西汀+氯氮平)和对照组(氯氮平+安慰剂)。在治疗前及治疗后12周末以阳性和阴性症状量表(PANSS)、生活质量综合评定问卷(GQOLI-74)和不良反应量表(TESS)进行评定。结果治疗12周末,研究组的PANSS总分、阴性因子分均低于治疗前,与对照组比较,差异有统计学意义(P<0.05或P<0.01),研究组心理健康维度及社会功能维度得分均明显高于对照组,均有显著性差异(P<0.05或P<0.01)。结论瑞波西汀合并氯氮平治疗精神分裂症阴性症状安全有效,并有利于改善精神分裂症的阴性症状及提高其生活质量。
Objective To observe the efficacy and side effects of reboxetine combined with clozapine in treating negative symptoms and on quality of life of the patients with schizophrenia. Methods In the random study, 114 inpatients with chronic schizophrenia were divided into two groups, with one treated by reboxetine combined clozapine （n= 57） and another by clozapine combined placebo （n= 57）. Effects and side effects were assessed with Positive and Negative Syndrome Scale （PANSS）, General Quality Of Life Inventory-74 （GQOLI-74） and Treatment Emergent Symptoms Scale （TESS） respectively before and after 12 weeks treatment. Results After 12 weeks, the reboxetine combined clozapine group has better effects in treating negative symptoms and in mental health and social function than placebo combined group. Conclusion Reboxetine combined clozapine is effective and safe in treatment of the negative symptom, and beneficial to improve the living qualities of schizophrenic patients.
出处
《中国健康心理学杂志》
2008年第2期133-135,共3页
China Journal of Health Psychology
