摘要
目的探讨心理干预在抗精神病药物致药源性肥胖中的作用。方法对160例首发精神分裂症住院患者随机分为研究组（80例,脱落5例）和对照组（80例,脱落11例）,研究组采取在抗精神病药物治疗＋心理干预,对其进行有关肥胖知识的学习、合理饮食、加强锻炼、良好的生活规律和心情等干预综合治疗措施,对照组单独抗精神病药物治疗方法。对2组入院和出院及出院后6个月、12个月、18个月和24个月随访时的体重进行比较。结果入院和出院时2组体重改变差异无显著性（P〉0.05）;随访结果比较,研究组（分别为66.95±10.51,67.05±10.51,67.09±10.55和68.19±10.79）和对照组（分别为72.48±9.96,73.01±9.89,73.36±10.07和75.00±9.18）,2组差异具有高度显著性（t=-3.23,-3.52,-3.64和-4.06;P〈0.01～0.001）。结论心理干预对抗精神病药物致药源性肥胖中具有显著的预防效果。
Objective To study the effect of the Psychological Intervention on lossing Weight with antipsychotic. Methods Total ly 160 first-episode inpatients who met the DSM-Ⅳ diagnosis criterion of schizophrenia were divided randomly into two groups： the experimental group （n=80, fall off 5 cases） received antipsychotie therapy with psycho-hehavi oral （learning reasonable-food and drink, to strengthen training, good life-rule, good attitude of mind） therapy, and the control groups （n=80, fall off 11 cases） only received the antipsychotic for 10 weeks, the weight were assessed by before post-discharge and follow-up conducted for 6 months and 12 months and 18 months and 24 months respectively. Results The weight was no significant difference on admission and discharge between two grcups（P〉0.05）. After 6 months and 12 months and 18 months and 24 months, the weight in experimental group （66.95±10. 51 ,67.05±10. 51, 67. 09±10. 55 and 68.19±10. 79） were significantly lower than those in control group （72.48±9.96, 73.01±9.89, 73.36±10. 07 and 75.00±9.18, P〉0.01-0. 001）. Conelusion The Psychological Intervention has significantly preventahle effect on weight gain with antipsychotic.
出处
《中国健康心理学杂志》
2008年第2期126-128,共3页
China Journal of Health Psychology
关键词
精神分裂症
抗精神病药物
肥胖
心理干预
Sehizophrenia
Antipsychotic
Weight gain
The Psychological Intervention
