摘要
目的:探讨碳酸锂联用丙戊酸钠治疗急性躁狂发作的疗效与安全性。方法:56例急性躁狂发作患者随机分成两组,分别给予碳酸锂合并丙戊酸钠(合用组)与单用碳酸锂(单用组)治疗6周。采用Beck-Rafaelsen躁狂量表(BRMS)评定疗效,治疗中出现的症状量表(TESS)及实验室检查评价安全性。结果:治疗结束时两组BRMS评分均显著降低,以合用组疗效显著较好而快。结论:碳酸锂联用丙戊酸钠治疗急性躁狂发作疗效优于单用碳酸锂,且起效快、安全性好。
Objective：To explore the efficacy and side effects of lithium carbonate with sodium valproate in the treatment of acute manic episode. Method： Fifty - six patients with acute manic episode were randomly assigned into two groups, lithium carbonate combined with sodium valproate and lithium carbonate alone for 6 weeks. Efficacy and side efiects were assessed with Bech-Rafaelsen mania rating scale （BRMS） and treatment emergant symptom scale （TESS） before treatment and ＇after treatment for 1,2,4,6 weeks. Results：As compared with the baseline scores, BRMS scores decreased significantly in beth groups after 6 weeks＇ treatment, and the scores decreased more markedly in conrbined group （lithium carbonate and sodium valproate） than in alone group（lithium carbonate）. Conclusion： The lithium carbonate combined with sodium valpreate to treat acute manic episode has better efficacy and fewer adverse events, and taking effect more quickly.
出处
《临床精神医学杂志》
2008年第1期51-52,共2页
Journal of Clinical Psychiatry
关键词
躁狂发作
碳酸锂
丙戊酸钠
manic episode
lithium carbonate
sodium valpreate
