摘要
目的:探讨引起住院精神分裂症患者体质量增加的相关因素。方法:首发住院精神分裂症患者72例分别于治疗前和治疗6周末测定体质量、血清瘦素、胰岛素、胰岛素抗体、糖化血红蛋白(HbA1C)、空腹血糖、血清胆固醇(T-CHO)及三酰甘油(TG)。结果:服抗精神病药后体质量有显著性增高(t=7.865,P=0.000)。体质量变化与服药种类(γ=-0.400,P<0.01)等有关。结论:影响住院精神分裂症患者体质量变化最主要的3个因素为:服用精神药物种类、初始三酰甘油及瘦素变化量。
Objective：To investigate the related factors contributing to weight gain of inpatients with schizophrenia. Method：72 inpatients with first-episode schizophrenia were recruited, examining body weight, serum leptin, insulin, insulin antibody, glycosylated hemoglobin （HbAtc ）, fasting plasma glucose, total cholesterol （T-CHO） and triglyceride （TG） before treatment and after 6 weeks of treatment respectively. Results： Compared with that before treatment, the body weight of post-treatment was significantly increased （t = 7. 865, P = 0.000）. The body mass gain was correlated with the kinds of antipsychotic drugs （y = - 0. 400, P 〈 0.01 ）, etc. Conclusion： The major factors that influence the inpatients＇ weight gain were the kinds of antipsychotic drugs, TG of prior to treatment and the change of leptin level.
出处
《临床精神医学杂志》
2008年第1期21-22,共2页
Journal of Clinical Psychiatry
