摘要
目的探讨晚期前列腺癌骨转移性疼痛的理想治疗方法。方法23例确诊为前列腺癌且有多处骨转移病灶伴有疼痛患者,经静脉滴注唑来膦酸同时,辅以核素89Sr静脉内注射内放疗及部分病灶外放射治疗。结果疼痛缓解率3个月为82.6%,6个月为91.3%,9个月为86.9%。骨转移病灶数量明显减少,肿瘤标志物PSA较前明显下降。结论该方案治疗前列腺癌骨转移性疼痛安全、有效,可以提高患者生活质量。
Objective To evaluate the effects of Zoledronic acid combined Strontium-89 palliative therapy in prostate cancer patients with bone metastases. Methods 23patients of prostate cancer with bone metastases received Zoledronic acid with strontium-89 chloride（^89Sr）, and part of them received radiotherapy. Results The pain was relieved. Relief occurred in 82.6% of the patients for 3 months, 91.3% for 6months and 86.9% for 9 months. The number of bone metastases and serum PSA was reduced. Conclusion Zoledronic acid with ^89Sr is effective palliative and more safe treatment for pain from bone metastases in patient with prostate cancer.
出处
《中国男科学杂志》
CAS
CSCD
2008年第1期28-30,共3页
Chinese Journal of Andrology
关键词
前列腺肿瘤
骨转移性疼痛
唑来膦酸
^89锶
放射疗法
prostatic neoplasms
pain, bone metastases
Zoledronic acid
strontium-89
radio therapy
