摘要
为探讨八氯二丙醚的致突变性和致畸性，采用Ａｍｅｓ试验、小鼠骨髓嗜多染红细胞微核试验、传统致畸试验进行了检测。结果发现：Ａｍｅｓ试验中仅有两个浓度的回变菌落数为阴性对照的两倍以上，但无剂量反应关系；致畸试验在８０，３２０和１６００ｍｇ／ｋｇ的染毒剂量条件下，没有发现明显的致畸作用。但１６００ｍｇ／ｋｇ的剂量对孕鼠和胎鼠都有一定的毒性作用。低剂量组胎鼠的体重和身长及尾长均高于阴性对照组。经统计学检验差异均有显著性（Ｐ＜０．０１）。
The mutagenicity and teratogenicity of octachlorodipropylether were detected with Ames test,PCE micronucleus test and traditional teratogenic test.The results showed that Ames test and micronucleus test were negative.No evident teratogenicity were found with its dose of 80,320 and 1600mg/kg,while certain toxicity had been found for pregnent rats and fetuse with the dose of 1600 mg/kg.The lenth and body weight of fetuses in 80 mg/kg were higher than those in the control group( P< 0.01).
出处
《环境与健康杂志》
CAS
CSSCI
CSCD
北大核心
1997年第3期107-109,共3页
Journal of Environment and Health
