摘要
目的 探讨妊娠期高血压疾病患者（hypertensive disorder complicating pregnancy，HDCP）血清钙卫蛋白水平的变化及其与该疾病发生的关系。方法采用双抗体夹心酶联免疫吸附法检测55例HDCP患者（其中妊娠期高血压20例，轻度子痫前期19例，重度子痫前期11例，子痫5例）和25例正常足月妊娠妇女血清钙卫蛋白水平。结果正常妊娠组、妊娠期高血压组、轻、重度子痫前期组及子痫组钙卫蛋白的质量浓度分别为[（420±78）、（443±62）、（512±83）、（598±74）和（749±92）]μg／L。子痫前期组及子痫组与妊娠期高血压及正常妊娠组比较，差异均有统计学意义（P〈0．01）；重度子痫前期组与轻度子痫前期组比较、子痫组与重度子痫前期组相比差异均有统计学意义（P〈0．01）；妊娠期高血压组与正常妊娠组比较差异无统计学意义（P〉0．05）。结论血清钙卫蛋白可能在HDCP的发生发展过程中起一定的作用。
Objective To discuss the relationship between serum level of calprotectin in advanced gestations and hypertensive disorder complicating pregnancy （HDCP）. Methods The serum levels of calprotectin were analyzed using enzyme-linked immunosorbent assay （ELISA）. Blood samples were obtained from 55 pregnant women at 31~39 weeks＇ gestation with HDCP （20 gestational hypertension,19 mild preeclampsia, 11 severe preeclampsia and 5 eclampsia）, and 25 normal pregnant women at 37-40^＋5 weeks＇ gestation served as control Results Serum calprotectin levels in normal, gestational hypertension, mild preeclampsia, severe preeclampsia and eclampsia group were [（420± 78）, （443 ± 62）, （512 ± 83）, （598± 74） and （749 ± 92）]μg/L, respectively. Serum levels of calprotectin in the preeclampsia and eclampsia groups were significantly higher than those in the gestational hypertension and normal group（P〈0. 01）, that of the severe preeclampsia group was significantly higher than the mild preeclampsia group（P〈0.05）, and that of the eclampsia group was significantly higher than the preeclampsia group （P 〈 0. 01）. However, no difference was found between the gestational hypertension and normal group （P 〉 0. 05 ）. Conclusion The increased serum level of calprotectin may participate in the genesis of HDCP.
出处
《中华围产医学杂志》
CAS
2008年第1期2-4,共3页
Chinese Journal of Perinatal Medicine
关键词
钙卫蛋白
妊娠并发症
心血管
高血压
妊娠末期
Calprotectin
Pregnancy complications, cardiovascular Hypertension Pregnancy trimester, third
