摘要
目的:观察非小细胞肺癌(NSCLC)组织中表皮生长因子受体(EGFR)和血管内皮生长因子(VEGF)的表达,并探讨二者可能的临床意义。方法:免疫组织化学染色比较82例NSCLC和20例非恶性肺组织中EGFR和VEGF的表达;观察NSCLC患者不同临床病理特征下EGFR和VEGF蛋白的表达情况,并分析二者表达的相关性。结果:NSCLC组织中EGFR、VEGF阳性表达率明显高于非恶性肺组织(53.66%vs0,62.20%vs25%,P<0.05)。EGFR表达在不同性别、不同病理类型(鳞癌vs腺癌)、有无淋巴结转移及不同TNM分期的NSCLC患者之间有统计学差异(P<0.05);VEGF表达在有无淋巴结转移及不同TNM分期的NSCLC患者之间有统计学差异(P=0.0001)。EGFR、VEGF高表达患者生存期短于各自的低表达患者(P<0.05)。NSCLC组织中EGFR和VEGF的表达具有相关性(rs=0.314,P<0.05)。结论:NSCLC组织中EGFR和VEGF存在过度表达,二者表达具有相关性,可作为判断NSCLC患者病情及预后的参考指标和靶向治疗靶点。
Objective.-To observe the expression of epidermal growth factor receptor （EGFR） and vascular endothelial growth factor （VEGF） in non-small cell lung cancer（NSCLC）, and to discuss its clinical significance. Methods： The expression of EGFR and VEGF was detected in 82 NSCLC and 20 non-malignant pulmonary samples by immunohistochemical method. The expression of EGFR and VEGF in NSCLC patients with various pathological characteristics was observed and the correlation between them was analyzed. Results： The positive rates of EGFR and VEGF in 82 NSCLC samples were obviously higher than those in the 20 non-malignant samples（53.66% vs 0 for EGFR, 62.20% vs 25% for VEGF, both P〈0.05）. The expression of EGFR in NSCLC samples was significantly correlated with the sex of patients, pathological types of cancer （squamous-cell carcinoma vs adenocarcinoma）, presence of lymph node metastasis, and TNM stages （P〈0. 05）. The expression of VEGF in NSCLC was correlated with lymph node metastasis and TNM stages （P〈0.05）. It was also noticed that higher expression of EGFR or VEGF was associated with poor prognosis of patients （P〈0.05）. The expression of EGFR was correlated with VEGF expression in pulmonary tissues of NSCLC patients（rs = 0. 314, P〈0.05）. Conclusion： EGFR and VEGF are over-ex- pressed in NSCLC tissues and the 2 are correlated with each other, which may serve as predicator for prognosis and a therapeutic target of NSCLC patients.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2008年第1期72-76,共5页
Academic Journal of Second Military Medical University
关键词
表皮生长因子受体
血管内皮生长因子
非小细胞肺癌
epidermal growth fator receptor
vascular endothelial growth factor
non-small lung cancer
