摘要
目的探讨脑梗死患者不同时期血清超敏C反应蛋白(hs-CRP)含量变化及其临床意义。方法采用酶联免疫吸附法(ELISA)检测50例脑梗死患者(观察组)不同时期hs-CRP含量和30例健康对照组人员hs-CRP含量的变化。结果(1)脑梗死患者第1、第3、第7、第21天hs-CRP含量较健康对照组明显增高,差异有统计学意义(P<0.05);第1、第3、第7天hs-CRP含量较第21天hs-CRP含量明显增高,差异有统计学意义(P<0.05)。(2)脑梗死患者血清hs-CRP含量与梗死灶体积及神经功能缺损程度呈正相关(P<0.01)。结论监测脑梗死患者血清hs-CRP含量变化有助于判断病灶大小、评估预后,对脑梗死的预测和干预处理有一定的临床价值。
Objective To investigate the change of serum high-sensitive C-reactive protein（hs-CRP） levels and its clinical significance in patients with cerebral infaretion.Methods The levels of serum hs-CRP in 50 patients with cerebral infarction at different periods（observation group） and 30 healthy subjects （control group） were detected by ELISA. Results （ 1 ）The levels of serum hs-CRP in observation group were significantly higher than those of control group at the lst,3rd,7th,21st day after stroke onset（ P 〈 0.05）.The levels of hs-CRP in observation group at the 1st,3rd,7th were significantly higher than that at the 21st day（ P 〈 0.05）. （2）The levels of hs-CRP in observation group were positively correlated with the vohane of cerebral infarction and the degree of neurological function defect （ P 〈 0.01 ）. Conclusion The changes of levels of serum hs-CRP may contribute to the evaluation of size of focus and prognosis, and to the prediction and intervention for cerebral infarction.
出处
《疑难病杂志》
CAS
2008年第2期71-73,共3页
Chinese Journal of Difficult and Complicated Cases
基金
福建省卫生厅青年科研基金(No.2002-1-15)
关键词
脑梗死
超敏C反应蛋白
预后
Cerebral infarction
High-sensitive C-reactive protein
Prognosis
