摘要
目的:了解林可霉素致不良反应发生的特点及一般规律。方法:对1995～2006年国内医药期刊报道的有关林可霉素致ADR293例进行统计、分析。结果:既往有ADR史85例(占29.01%);单独用药为128例(占43.69%),过量给药为177例(占60.41%),静脉滴注给药为198例(占67.58%);122例(占41.64%)ADR发生在用药过程中;ADR以变态反应为主,为135例(占46.08);273例(占93.17%)治愈或好转,19例(占6.48%)死亡。结论:林可霉素所致ADR可累及全身各个系统,严重者可致死亡,使用时须慎重考虑ADR史、用量、给药途径等相关因素。
OBJECTIVE： To study the characteristics and regular patterns of adverse drug reactions（ADR） caused by lincomycin .METHODS：A total of 293 lincomycin- induced ADR case reports published in domestic medical journal between 1995 and 2006 were statistically analyzed.RESULTS： Of the patients reviewed, 85（29.01% ） had ADR history, 128（43.69%） used single kind of drugs, 177（60.41% ） used drugs overdosely, 198（67.58% ） received drugs by intravenous drop infusion, 122（41.64% ） had their ADR occurred in the administration of lincomycin, allergic reactions（ 135 cases, or 46.08% ） were the predominant manifestations of ADR, 273（93.17 % ） were cured or improved, and 19（6.48 % ） died. CONCLUSION ： The ADR induced by lincomycin may involve systemic systems,and it may even cause death in severe cases,therefore, one must take into considerations of factors such as ADR history,dosage and router of medication and so on in the use of lincomycin.
出处
《中国药房》
CAS
CSCD
北大核心
2008年第5期378-380,共3页
China Pharmacy
关键词
林可霉素
不良反应
合理用药
文献分析
Lincomycin
Adverse drug reaction
Rational administration
Literature analysis
