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细胞周期蛋白D1对被动致敏的人气道平滑肌细胞增殖调控的影响 被引量:1

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摘要 支气管哮喘(以下简称哮喘)的本质是气道慢性炎症,并在此基础上出现气道高反应性和气道重塑;而气道平滑肌增殖在哮喘气道重塑中起重要作用,是不可逆性气流阻塞、持续气道高反应性的重要病理基础。细胞分裂增殖必须经过细胞周期有规律地运行,细胞周期蛋白对细胞周期运行起关键的调控作用。已有研究证实,在人气道平滑肌细胞(HASMC),细胞周期蛋白D1表达增加可促进细胞增殖,但有关细胞周期蛋白D1对哮喘HASMC增殖调控的研究目前少见报道。
出处 《中华内科杂志》 CAS CSCD 北大核心 2008年第2期143-144,共2页 Chinese Journal of Internal Medicine
基金 国家自然科学基金(30670925)
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