摘要
目的探讨大肠癌侵袭和转移螺旋CT征象与癌组织中VEGF及iNOS的表达以及两者之间的关系。方法对64例经手术病理证实且行螺旋CT平扫、动静脉期双期增强的大肠癌患者,观察每个病灶的浆膜侵犯和淋巴结转移情况。用免疫组化方法检测癌组织中VEGF及iNOS表达情况,并分析其与螺旋CT征象的关系。结果螺旋CT征象上肿瘤的浆膜侵犯、淋巴结转移与VEGF及iNOS蛋白表达有关(P<0.05)。结论大肠癌侵袭和转移CT征象可以在一定程度上反映VEGF及iNOS的表达。
Objective To evaluate the correlation of spiral CT features of invasion and metastasis with the expression of VEGF and iNOS in colorectal carcinoma and their interacting relationship.Methods Plain spiral CT scan and enhanced dual-phase spiral CT scan at both arterial and venous phase were performed in 64 patients with pathologically proved colorectal carcinoma,serosa infiltration and lymph node metastasis of each lesion were observed.The expression of VEGF and iNOS in tumor specimens was estimated with immunohistochemical technique,the relationship between CT findings and the expression of the two proteins were analyzed and evaluated.Methods Serosa infiltration and lymph node metastasis on spiral CT features significantly correlated with the expression of VEGF and iNOS（P〈0.05）.Conclusion Spiral CT features of invasion and lymph node metastasis could reflect the expression of VEGF and iNOS in colorectal carcinoma.
出处
《中国现代药物应用》
2008年第1期9-11,共3页
Chinese Journal of Modern Drug Application
