摘要
目的观察地尔硫缓释剂对高血压合并冠心病患者疗效。方法２９例高血压合并冠心病患者口服地尔硫缓释剂９０ｍｇ，２／ｄ，用药４周，应用２４ｈ动态血压和动态心电图观察用药前后血压和缺血性ＳＴ段的变化。结果用药后２４ｈ收缩压（ＳＢＰ）从１４５±９降至１２７±１２ｍｍＨｇ，舒张压（ＤＢＰ）从１０６±１１降至８２±１５ｍｍＨｇ（Ｐ＜０．０５）；ＳＢＰ负荷由６４±９％降至３８±９％（Ｐ＜０．０１），ＤＢＰ负荷由５４±１４％降至２９±１０％（Ｐ＜０．０１）。心肌缺血发作频率从４．３±２．０降至２．３±１．０／２４ｈ，缺血总时间（ｍｉｎ／２４ｈ）从１６．９±３．９降至９．４±２．９，最大ＳＴ段下移由１．４±０．５ｍｍ降为０．８±０．３ｍｍ（Ｐ＜０．０１）。结论地尔硫缓释剂能显著改善高血压合并冠心病患者的心肌缺血和降低患者血压。
Aim\ \ To investigate the effects of diltizem SR on patients with hypertension and angina.\ Methods\ 29 patients with angina and hypertension were administering sustained release diltizem 90 mg bid for 4 weeks. All patients wer monitored by 24 h noninvasive blood pressure mornitoring and ambulatory ECG.\ Results\ 24 h BP decreased from 145/106 to 127/82 mmHg(P<0.05); systolic blood pressure load decreased from 64±9% to 38±9%, diastolic blood pressure load decreased from 54±14% to 29±10%(P<0.01).\ Frequency of ischemic episodes decreased from 4.3±2.0 to 2.3±1.0 episodes/24 h,the total ischemic time decreased from 16.9±3.6 to 9.4±2.9 min/24 h,and the max decrease of ST segment from 1.4±0.5 to 0.8±0.3 mm(P<0.05).\ Conclusion\ Diltizem SR is effective for the patients with angina and hypertension.
出处
《高血压杂志》
CSCD
1997年第2期140-141,共2页
Chinese Journal of Hypertension
