摘要
目的检测42例幽门螺杆菌(HP)感染相关的消化性溃疡外周血白细胞介素-2(IL-2)、可溶性白细胞介素2受体(sIL-2R)、白细胞介素6和8(IL-6和IL-8)和T淋巴细胞亚群,以探讨其免疫学发病机制。方法IL-2、sIL-2R、IL-6、IL-8和T淋巴细胞亚群检测,分别采用ELISA、双抗体夹心ELISA和APAAP法进行。结果CD3+、CD4+细胞百分率、CD4+/CD8+比值和IL-2水平均显著低于对照组(P均<0.01),而CD8+细胞百分率、sIL-2R、IL-6、IL-8水平均显著高于对照组(P均<0.01)。结论HP感染相关的消化性溃疡患儿细胞免疫功能低下且紊乱,该患儿机体的免疫功能障碍在该病的发生中起一定作用。
Objective：To examine interleukin-8.6.2（IL-8.6.2）,serum soluble IL-2 receptor（sIL-2R） levels and T lymphocyte subsets in peripheral blood of 42 childhood peptic ulcer disease correlated with helicobacter pylori（HP） and analyse its immnunological pathogenesis.Methods：IL-8 and IL-6,IL-2 and sIL-2R as well as T lymphocyte subsets were assayed by double antibody sandwich ELISA,ELISA and APAAP Methods.Results：The percentages of CD3＋ and CD4＋ and the ratio of CD4＋/ CD8＋ cells as well as IL-2 level in the patients were significantly lower ﹙P〈0.01,respectively,while sIL-2R,IL-6 and IL-8 levels were higher than those in normal controls ﹙P〈0.01,respectively﹚,respectively.Conclusion：Cellular immunity function is low and disorder in childhood peptic ulcer disease correlated with HP and this disorders in cellular immunity function have some effect in its pathogenesis.
出处
《中国优生与遗传杂志》
2008年第1期119-120,共2页
Chinese Journal of Birth Health & Heredity
关键词
小儿
幽门螺杆菌
消化性溃疡
细胞免疫
Children
Helicobacter pylori
Peptic ulcer
Cellular immunity function
