摘要
目的:探讨包括系统性红斑狼疮(SLE)、原发干燥综合征(PSS)、混合性结缔组织病(MCTD)及未分化结缔组织病(UCTD)其血液系统损害与血中自身抗体的相关性。方法:分析179例结缔组织病患者临床及实验室资料,采用χ2检验及Logistic回归分析法进行统计学分析。结果:179例结缔组织病患者中63.7%出现血液系统受损,其中贫血42.5%,白细胞减少38.0%及血小板减少12.8%。抗SSA、SSB抗体阳性率血液受损组(72.8%,25.4%),尤其多系受损组(81.4%,32.6%)高于无血液受损组(50.8%,10.8%);抗ds-DNA抗体阳性率多系受损组(27.9%)高于无血液受损组(12.3%);抗SSA抗体阳性率单系白细胞受损组(90.0%)显著高于无血液受损组(50.8%);仅抗SSA抗体阳性率与血液系统损害呈正相关并与白细胞减少关系最密切(P=0.025)。SLE患者抗ds-DNA抗体及UCTD患者抗SSA抗体与血液受损有关。全部患者血液受损组IgG升高水平比无血液受损组高。结论:血液系统是结缔组织病易侵犯的器官,贫血最常见。抗SSA抗体可能参与了结缔组织病血液损害发生机制,尤其与白细胞减少关系最密切。
Objective： To investigate the relationship between impairment of hematological system and autoantibodies in four kinds of connective tissue diseases,including systemic lupus erythematosus （SLE）,primary sjogren＇s syndrome （PSS）,mixed connective tissue disease （MCTD） and undifferentiated connective tissue disease （UCTD）. Methods： Retrospective investigation of 179 patients with connective tissue diseases. The clinical data and immunological parameters were reviewed and analyzed with χ^2 and Logistic methods. Results： Of 179 patients with connective tissue diseases, there were 63.7% patients appeared impairment of hematological system including anemia （42.5%）,leucopenia （38.0%） and thrombocytopenia （ 12.8% ）. Positive ratios of anti-SSA and anti-SSB antibodies in group with impairment of hematological system（ 72.8% and 25.4% ）, especially in group with impairment of muhisystem（ 81.4% and 32.6% ） were higher than those in the normal group （50.8% and 10.8% respectively ）. Positive ratio of anti-ds-DNA antibodies in group with impairment of muhisystem （27.9%） was higher than that of normal group （ 12.3% ）. Positive ratio of anti-SSA antibody in group of leucopenia （90.0%） was much higher than that of normal group （50.8%）. After Logistic regression analysis, only positive ratio of anti-SSA antibody was related with impairment of hematological system （P = 0.025 ）, especially with leucopenia. Of patients with SLE, positive ratio of anti-ds-DNA antibody was related with impairment of hematological system. Of patients with UCTD,positive ratio of anti-SSA antibody was related with impairment of hematological system. Of patients with connective tissue diseases, the increase level of IgG in group of impairment of hematological system was higher than that of normal group. Conclusion： Impairment of hematological system always happens in connective tissue diseases, anemia is the most common. Anti-SSA antibody might take part in the mechanism of impairment of h
出处
《天津医药》
CAS
北大核心
2008年第1期18-21,共4页
Tianjin Medical Journal
关键词
结缔组织疾病
血液
红斑狼疮
系统性
抗体
抗核
connective tissue diseases blood lupus erythematosus,systemic antibodies,antinuclear
