摘要
目的:探求中西医结合治疗围绝经期综合征中尼尔雌醇的最低有效剂量。方法:98例围绝经期综合征患者随机分为5组,A组以尼尔雌醇全量替代治疗;B-E组分别以中药配伍全量、1/2量、1/4量和1/8量尼尔雌醇进行治疗,通过比较治疗前、后Kupperman评分及血清激素E2、FSH、LH,来评估治疗效果。结果:5组治疗前、后Kupperman评分均有显著差异,A组与B组、C组、D组比较均有显著差异,而B组、C组、D组间及A组、E组间差异无显著性。结论:初步表明补肾疏肝法中药联合应用不同剂量尼尔雌醇治疗围绝经期综合征有明显效果。其中中N+1/4量尼尔雌醇,不仅可获得良好疗效,而且可减轻雌激素副作用。
Objective： To explore the minimal effective dose of nilestriol by treating permenopause syndrome with the method of Traditional Chinese Medicine and nilestriol. Methods： Ninety-eight cases with permenopause syndrome were divided into five groups at random. Group A were treated with the pure nilestriol replacement therapy; group B-E were respectively treated with Chinese herbal medicine combined with the whole dose of nilestriol, with the half dose of nilestriol, with the 1/4 dose of nilestriol, and with the 1/8 dose ofnilestriol. The curative effect was evaluated by using Kupperman grade and observing the changes of the level of E2, LH, FSH in serum before and after treatment. Results： There was a significant difference in Kupperman grade before and after treatment among five groups.The difference of that between group A and B, group A and C, group A and D was significant. But it was not significant among group B, C, D and neither was between group A and E. Conclusion： It initially indicates that it is an effective way to treat perimenopause syndrome with Chinese herbal medicine with tonifying kidney and smoothing liver combined with different doses of nilestriol. Furthermore, the method of Chinese herbal medicine combined with 1/4 dose of nilestriol not only can achieve content curative effect, but also decrease the side effect of estriol.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2008年第1期32-35,共4页
Reproduction and Contraception
关键词
围绝经期综合征
中西医结合治疗
激素替代疗法(HRT)
perimenopause syndrome
treatment with the combination of Traditional Chinese Medicine and Western Medicine
hormone replacement therapy（HRT）
