摘要
目的探讨脾窦岸细胞血管瘤的临床、影像学特征和病理组织学、免疫组织化学在诊断中的价值、鉴别诊断的要点及治疗方式。方法回顾性分析我院1例脾窦岸细胞血管瘤患者的临床资料,影像学的检查、大体及光镜观察、免疫组织化学方法检测及手术治疗的效果。结果脾窦岸细胞血管瘤的临床症状不典型,病理学特征性表现为:瘤结节位于脾红髓内,由相互吻合的血管腔构成,呈迷路样分布,常有假乳头样结构突入腔内,胞质内常见含铁血黄颗粒。免疫组化提示:FⅧRA g、CD 34、CD 68、CD 31、Lyso均为(+),患者手术切除脾脏取得良好临床疗效。结论脾窦岸细胞血管瘤是一种罕见的脾血管源性肿瘤。诊断主要依靠病理组织学及免疫组织化学,治疗主要是手术行脾脏切除,因可合并恶性肿瘤,应进行仔细检查及密切随访。
Objective To investigate clinical and imageological character,the value in the diagnosis of histological and limmuno- histochemical study,treatment and prognosis of littoral cell angioma of spleen. Methods The clinical data of 1 patient with littoral cell angioma were analyzed retrospectively in our hospital. The imageological examination and morphologic characteristics were studied and some tumor-specific antigens were detected in the case with SP immunohistochemistry staining. The effect of perative treatment and other treatment were researched. Results The clinical feature of the disease was atypical. LCA was characterized pathologically by anastomosing vascular channels. FⅦ RAg, CD34, CD68, CD31 and Lysozyme showed strong expression in the case. After being carried out surgical resection, the patient took good effect. Conclusion LCA is a rare vascular lesion of the spleen. It＇s diagnosis is on the basis of microscopic and immunohistochemical features. Operative treatment is the effective measure for the patients. The disease may be associated with maligant neoplasms,so close follow-up and careful investigation are strongly recommended.
出处
《东南国防医药》
2007年第6期422-424,共3页
Military Medical Journal of Southeast China
关键词
脾肿瘤
窦岸细胞
血管瘤
免疫组织化学
Spleen neoplasms
Littoral cell
Hemangioma
Immunohistochemistry
