摘要
目的:研究银杏叶提取物(GBE)对脑缺血再灌注大鼠丙二醛(MDA)、超氧化物歧化酶(SOD)、血液流变学指标的影响。方法:Wister大鼠24只,随机分为3组:假手术组、模型组、GBE组,每组8只。检测各组动物脑组织MDA和SOD活性的变化及血液流变学指标。结果:与假手术组比较,模型组血中MDA含量显著升高(P<0.01),SOD含量显著降低(P<0.01),血液流变学各指标显著升高(P<0.01),GBE组SOD和MDA含量无显著性变化(P>0.05);血液流变学血液黏度有所升高(P<0.05),红细胞压积及纤维蛋白无显著性变化(P>0.05)。与模型组比较,GBE组血中MDA含量有显著性降低(P<0.05),SOD含量有显著性升高(P<0.01)。结论:GBE能降低脑缺血再灌注大鼠MDA含量、增加SOD含量,改善血液流变学指标,对脑缺血再灌注大鼠脑组织有保护作用。
OBJECTIVE To study the proective effect of Ginkgo biloba extraction on cerebral ischemia-reinfusion rats. METHODS 24 wistar rats were divided randomly 3 groups（sham operated group, model group and GBE Group）. The activities oi superoxide dismutase （SOD）, the content of malondialdehyde（MDA） in cerebra and blood theology were checked. RESULTS Compared to sham operated group, MDA and blood theology in model group were decreased and SOD were increased （P〈0.01 ） but no change in GBE group （P〉0.05） except blood rheology. Compared to model group, MDA and blood rheology in GBE group were decreased and SOD were increased （P〈0.01 or P〈0. 05）. CONCLUSION GBE could significantly decrease the content of MDA and markedly increase the activity of SOD. It has a significant protective effect on cerebral ischemia reperfusion injury in rats.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2007年第12期1705-1707,共3页
Chinese Journal of Hospital Pharmacy
