摘要
目的本实验旨在验证异丙酚对脑复苏是否有一定的治疗作用。方法20只大鼠随机分为两组,异丙酚组(P,n=10)和乳剂组(L,n=10)。建立窒息型心跳骤停大鼠心肺脑复苏的模型,心肺复苏成功后P组给予异丙酚10mg/kg静脉推注,继之以30mg/(kg·h)速率持续输注1小时;L组则以等容积的1%脂肪乳剂按同样方式处置。复苏后进行神经功能缺损评分。结果两组之间心肺复苏后1、2、7天的神经功能缺损评分均无显著性差异,P>0.05。结论异丙酚不能影响窒息型心跳骤停大鼠复苏后1、2、7天的神经功能缺损评分。
Objective To investigate the effects of propofol on neural deficit scores after cardiac arrest induced by asphyxiation in rats. Methods 20 rats were randomly divided into propofol group （n = 10） and lipid group （n = 10）. After suffering 8 rain asphyxiation and cardiopulmonary resuscitation （CPR）, rats in propofol group were subjected to propofol therapy （10mg/kg intravenous bolus, then 30mg/（kg·h） infusion for one hour）, while rats in lipid group were subjected to the vehicle of propofol（ not containing propofol） therapy in same way. The tests of Neural Deficit Scores（NDS） were performed at 24 hours, 48 hours and 7dayes after cardiopulmonary resuscitation respectively. Results There was no significant statistical difference between the two groups in NDS. Conclusion Propofol（ 10mg/kg intravenous bolus,then 30mg/（kg·h） infusion for one hour）can not improve the NDS .
出处
《宁夏医学杂志》
CAS
2008年第1期9-10,共2页
Ningxia Medical Journal
