期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

转录因子Sp1与肝纤维化发生关系的研究现状

下载PDF
导出
摘要 转录因子Sp1与肝纤维化发生的关系日益受到人们的关注,Sp1可以通过调控多种致纤维化因子或抗纤维化因子的基因转录,从而影响肝纤维化的发生和发展,Sp1还明显影响肝星状细胞的活化和增殖。本文对Sp1在肝纤维化中的作用作一综述。
作者 陈浩 周宇
机构地区 广东医学院附属医院消化内科
出处 《实用肝脏病杂志》 CAS 2008年第1期63-67,共5页 Journal of Practical Hepatology
关键词 肝纤维化 转录因子SP1 发生 基因转录 发展 肝星状细胞
分类号 R575.2 [医药卫生—消化系统]
  • 相关文献

参考文献25

  • 1LEE JA,SUH DC,KANG JE,et al.Transcriptional activity of Sp1 is regulated by molecular interactions between the zinc finger DNA binding domain and the inhibitory domain with corepressors,and this interaction is modulated by MEK[J].J Biol Chem,2005,280(30):28061-28071. 被引量：1
  • 2薛丽香,翁默,吴军峰,张宗玉,童坦君.Sp1和Sp3介导的转录调控[J].中国生物化学与分子生物学报,2006,22(2):106-110. 被引量：10
  • 3CHU SJ,THOMAS J.Spl:Regulation of gene expression by phosphorylatian[J].Gene,2005,348(28):1-11. 被引量：1
  • 4YONGSEOK K,VLAD R,SHIN GC,et al.Transcriptional activation of tansforming growth factor β1 and its receptors by the kruppe-like factor Zf9/core promoter-binding prerein and Spl[J].J Biol Chem,1998,273(50):33750-33758. 被引量：1
  • 5HUANG W,ZHAO S,AMMANAMANCHI S,et al.Trichostatin A induces transforming growth factor beta type Ⅱ receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1*NF-Y complex[J].J Biol Chem,2005,280(11):10047-10054. 被引量：1
  • 6RAFTY L A,KHACHIGIAN LM.Sp1 phosphorylation regulates inducible expression of platelet-derived growth factor B-chain gene via atypical protein kinase C-{zeta}[J].Nucl Acids Res,2001,29(5):1027-1033. 被引量：1
  • 7BONELLO MR,KHACHIGIAN LM.Fibroblast growth factor-2 represses platelet-derived growth factor receptor-{alpha}(PDGFR-{alpha}) transcription via ERK1/2-dependent Sp1 phosphorylation and an atypical cis-acting element in the proximal PDGFR-{alpha} promoter[J].J Biol Chem,2003,279(4):2377-2382. 被引量：1
  • 8TSYTSYKOVAA V,GOLDFELD AE.Inducer-specific enhanceosome formation controls tumor necrosis factor alpha gene expression in T lymphocytes[J].Mol Cell Biol,2002,22(8):2620-2631. 被引量：1
  • 9KAYTOR EN,ZHU JL,PAO CI,et al.Insulin-responsive nuclear proteins facilitate Sp1 interactions with the insulin-like growth factor-Ⅰ gene[J].J Biol Chem,2001,276(40):36896-36901. 被引量：1
  • 10MA W,LIM W,GEE W,et al.The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated human macrophages[J].J Biol Chem,2001,276(17):13664-13674. 被引量：1

二级参考文献27

  • 1Yu B,Datta P K,Bagchi S.Stability of the Sp3-DNA complex is promoter-specific:Sp3 efficiently competes with Sp1 for binding to promoters containing multiple Sp-sites.Nucleic Acids Res,2003,31(18):5368 ～ 5376 被引量：1
  • 2Yang X,Su K,Roos M D,Chang Q,Paterson A J,Kudlow J E.Olinkage of N-acetylglucosamine to Sp1 activation domain inhibits its transcriptional capability.Proc Natl Acad Sci USA,2001,98(12):6611～ 6616 被引量：1
  • 3Hagen G,Muller S,Beato M,Suske G.Sp1-mediated transcriptional activation is repressed by Sp3.EMBO J,1994,13(16):3843 ～ 3851 被引量：1
  • 4Emili A,Greenblatt J,Ingles CJ.Species-specific interaction of the glutamine-rich activation domains of Sp1 with the TATA box-binding protein.Mol Cell Biol,1994,14(3):1582 ～ 1593 被引量：1
  • 5Taatjes D J,Tjian R.Structure and function of CRSp/Med2; a promoter-selective transcriptional coactivator complex.Mol Cell,2004,14(5):675 ～ 683 被引量：1
  • 6Jang S I,Steinert P M.Loricrin expression in cultured human keratinocytes is controlled by a complex interplay between transcription factors of the Sp1,CREB,AP1,and AP2 families.J Biol Chem,2002,277 (44):42268 ～ 42279 被引量：1
  • 7Sun J M,Chen H Y,Moniwa M,Eitchfield D W,Seto E,Davie J R.The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2.J Biol Chem,2002,277(39):35783 ～ 35786 被引量：1
  • 8Sun JM,Spencer VA,Li L,Yu Chen H,Yu J,Davie J R.Estrogen regulation of trefoil factor 1 expression by estrogen receptor alpha and Sp proteins.Exp Cell Res,2005,302(1):96 ～ 107 被引量：1
  • 9Lu F,Zhou J,Wiedmer A,Madden K,Yuan Y,Lieberman P M.Chromatin remodeling of the Kaposi' s sarcoma-associated herpesvirus ORF50 promoter correlates with reactivation from latency.J Virol,2003,77(21):11425 ～ 11435 被引量：1
  • 10Ishii K,Laemmli U K.Structural and dynamic functions establish chromatin domains.Mol Cell,2003,11(1):237 ～ 248 被引量：1

共引文献9

实用肝脏病杂志
2008年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部