摘要
用水相共沉淀法制备了超顺磁的Fe_3O_4纳米粒子,并通过Michael加成将2-(甲基丙烯酰氧基)乙基-2-(三甲基氨基)乙基磷酸酯(MPC)共价键合到氨基化的Fe_3O_4纳米粒子表面.与未修饰MPC的Fe_3O_4纳米粒子相比,修饰了MPC的纳米粒子能大大减少蛋白质的非特异性吸附,延长了复钙化凝血时间,并具有良好的生物相容性.
Superparamagnetic magnetite nanoparticles of 10-20 nm diameter was prepared by chemical coprecipitation in aqueous solution. Bioinspired 2-methacryloyloxyethyl phosphorylcholine （MPC） was covalently immobilized onto magnetite nanoparticles by Michael addition. Biological properties of the MPC modified magnetite nanoparticles were evaluated using protein adsorption assay and the plasma recalcification time （PRT）. The results showed that MPC modified magnetic nanoparticles can strongly reduce nonspecific protein adsorption and had much longer plasma recalcification time. The magnetite nanoparticles modified by MPC have outstanding biocompatibility.
出处
《材料研究学报》
EI
CAS
CSCD
北大核心
2007年第6期589-592,共4页
Chinese Journal of Materials Research
基金
国家高技术研究发展计划2006AA03Z329
国家自然科学基金20774082
浙江省科技计划项目2007C24008
教育部"新世纪优秀人才计划"NCET-05-0527资助项目~~
