摘要
目的:合成吡唑类衍生物并研究其抗流感病毒活性。方法:以1-甲氧甲酰基-5-氨基-1H-吡唑-3-甲酸乙酯为原料,同氯乙酰氯和取代哌嗪反应得到含氮化合物;同硫氰酸钠、酰氯反应得到酰氨基硫脲。结果与结论:合成了7个新化合物;其中部分化合物具有一定抗流感病毒活性。
Objective ： To synthesize pyrazole and its analogs and evaluate their anti-influenza virus activity. Methods： pyrazole was reacted with chloroacetyl chloride and substituted piperazidine to obtain nitrogenous compounds and reacted with sodium thiocyanate and acyl chloride to obtain substituted thiourea. Results and Conclusion： 7 new compounds have been synthesized, among them 3b had antiinfluenza virus activity.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2007年第24期2043-2044,2053,共3页
Chinese Journal of New Drugs
基金
天津市科技发展计划项目(043185111-7)
