摘要
目的：研究益舒软肝丸逆转肝硬化的作用机理。方法：以CCL4复合因素法建立肝硬化模型，首先制备出肝硬化的实验动物模型，造模结束后，连续灌胃给药3个月。检查ALT、AST，A／G、CHE；HA、LN、PⅢNP、Hyp；SOD、MDA。结果：与模型对照组大鼠比，用药组组织切片显示汇管区有少量纤维组织增生，但未见假小叶结构；肝功能指标ALT、AST减少，A／G、CHE增加，肝功能有显著好转；HA、LN、PⅢNP、Hyp水平显著降低，肝纤维化程度降低；MDA水平降低。结论：说明益舒软肝丸有明显的抗肝硬化的作用，作用机制可能与抗脂质过氧化，保护肝细胞有关。
Objective： To investigate the effect and mechanism of Yishuruan- ganwan （YS） on liver fibrosis induced by CCL4. The main contents are as follows. Methods： 80 healthy clean rats were divided into normal group, model group. The animal models were induced by complex factors of CCL4, foods of high fat. At the end of inducing model, model group divid into model group, three different dose groups. The course of treat is 12 weeks. Detect the degress of histopathology changes of liver in CCL4 - induced cirrhosis, the indices of liver and spleen, and the level of ALT^AST and HA ,LN ,Pill NP in serum, and the level of A/G 、 CHE, and the content of Hyp and MDA in liver tissue induced by CCL4. Results： Comparing with the model group, the degress of histopathology changes of liver in CCL4 - induced cirrhosis were ameliorated remarkably by YS treatment, the decreased indices of liver and spleen, and the decreased level of ALT, AST and HA, LN,Plll NP in serum, and the increased level of A/G ,CHE, and the decreased content of Hyp and MDA in liver tissue duced by YS treatment. Conclusions： In earlier cirrhosis of liver, The mechanisms and hepatocyte protection effect. induced by CCL4 were significantly reshort, YS has obvious treatment with the possibly due to its anti - lipoperoxidation
出处
《实用医学进修杂志》
2007年第4期209-212,227,共5页
Journal of Practical Training of Medicine
关键词
益舒软肝丸
肝硬化
逆转
中医药疗法
实验研究
Yishuruanganwan
cirrhosis
recovery
therapy of traditional Chinese medicine
experimental study
