摘要
目的探讨贵阳市社区老年人血压、脉压及平均动脉压(MAP)与认知功能之间的关系。方法采用多级整群抽样法,抽取贵阳市城区年龄≥60岁的3229例老年人作为研究对象。通过问卷调查和体格检查相结合,收集相关资料,用简易智能状态检查量表(MMSE)进行认知功能评价。结果随着老年人收缩压水平的升高,MMSE呈下降趋势,差异有显著性意义(F=17.6,P<0.01),轻度认知障碍(MCI)患病率随着老年人收缩压水平的升高逐渐增高,差异有显著性意义(χ2趋势=4.76,P<0.05)。脉压越大,MMSE越低,差异有显著性意义(F=27.1,P<0.01)。随着脉压的增加,MCI患病率也逐渐增加(χ2趋势=5.63,P<0.05)。MAP与MMSE呈曲线关系,MAP在90～109mmHg(1mmHg=0.133kPa)时MMSE最高,≤70mmHg或≥110mmHg时MMSE逐渐降低。logistic回归分析显示,中、重度高血压老年人发生MCI的危险高于正常老年人。结论高血压、高脉压、过高或过低的MAP对MCI的发生有重要影响。
Objective To investigate the association between blood pressure and cognitive function in community-based elderly people aged 60 and over in Guiyang City. Methods Using multistage sampling technique,general conditions and healthy status were surveyed in 3 229 old people aged 60 years and over. Blood pressure and the mini-mental state examination （MMSE） score were measured. Chi-square test, t test and ANOVA were used for data analysis. Logistic regression was used in multivariate analysis. Results Among different systolic pressure groups,MMSE score decreased with increasing blood pressure level（ F = 17.6, P 〈0.01）. Increasing prevalence of cognitive impairment was found in the subjects with hypertension（χ^2trend=4.76, P〈0.05）. Decreased MMSE score was found in those with high pulse pressure （ F=27.1, P〈0.01）. Prevalence of cognitive impairment increased in the subjects with high pulse pressure（ χ^2trend=5.63, P〈0.05）. There was a curve association between mean arterial pressure （MAP） and MMSE score. MMSE score was highest when MAP was 90～109 mm Hg. The subjects with 470 mm Hg or ≥110 mm Hg MAP had lower MMSE score. Logistic regression analysis indicated that hypertension was a risk factor for mild cognitive impairment （MCI）. Conclusion Hypertension, high pulse pressure, and high or low MAP had significant impact on MCL MAP around 100 mmHg might reduce prevalence of MCI. Prevention and control of hypertension might be helpful to slowing down impairment of cognitive function among old people.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2008年第1期7-10,共4页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
贵州省省长资金(黔科教办200407)
贵州省教育厅自然科学研究项目(黔教科2005108)
关键词
高血压
认识障碍
血压
危险因素
hypertension
cognition disorders
blood pressure
risk factors
