摘要
为探讨Ｂｏｒｎａ病病毒与人类精神疾病的关系，采用套式逆转录酶／聚合酶链反应技术检测７２例精神病病人和４０名健康献血者周围血单核细胞的Ｂｏｒｎａ病病毒ｐ２３基因片段。结果显示，精神分裂症组的ｐ２３阳性检出率（９．４％）稍高于健康对照组（７．５％），但差异无显著性；双相情感障碍组的阳性检出率（２１．１％）明显高于健康对照组（Ｐ＜０．０５）。提示人类双相情感障碍可能与Ｂｏｒｎａ病病毒感染有关。
Borna disease virus (BDV) is a neurotropic virus which can cause the infection of central nerves system in animals. In order to research the relationship between BDV and the human psychiatric disorders, the p23 fragment of BDV in peripheral blood mononuclear cells from 72 psychiatric patients and 40 healthy donors were examined by nested RT PCR. We found that the p23 RNA positive rate in schizophrenia (9.4%) is higher than in donors (7.5%) but without statistical significance. The positive rate in bipolar disorders (21.1%) is significantly higher than in donors ( P < 0.05). The result suggests the bipolar affective disorders may closely related to the infection of BDV.
出处
《中华精神科杂志》
CAS
CSCD
1997年第3期136-138,共3页
Chinese Journal of Psychiatry
关键词
精神病
BORNA病病毒
p23基因片断
Schizophrenia Affective disorders Borna disease virus Genes, viral
