摘要
目的探讨p53和Ki-67在DLBCL免疫类型中的表达及相互关系。方法采用免疫组化MaxVision法检测p53和Ki-67在DLBCL免疫类型中和反应性增生的淋巴结中的表达。结果25例GCB中p53的阳性率为16.0%,35例non-GCB中p53的阳性率为45.7%,两者之间P<0.01;25例GCB中Ki-67高表达4例,35例non-GCB中Ki-67高表达18例,两者之间P<0.01;p53阳性DL-BCL20例中ki-67高表达12例,p53阴性DLBCL40例中Ki-67高表达10例,两者正相关。结论p53、Ki-67的表达与DLBCL的免疫类型相关,GCB类型中低表达,non-GCB类型中高表达。
Objective To study the expression of p53 and its relationship with expression of Ki-67 in the immunology types of diffuse large B-cell lymphoma（DLBCL）. Methods The expression of p53 and Ki-67 in the immunology types of DLBCL and reactive hyperplasia lymphoid node, were detected by MaxVision immunohistochemicalmethod. Results In 60 specimens of DLBCL patients, immunology type： GCB 25 cases, non-GCB 35 cases. GCB 25 cases, the positive rates of p53 were 16. 0%,non-C, CB 35 cases, the positive rates of p53 was 45. 7%. GCB 25 cases, Ki-67 were high expression in 4 specimens;non-GCB 35 cases, Ki-67 were high expression in 18 specimens（P〈0. 01 ）. Ki-67 were high expression in 12 specimens in 20 specimens of DLBCL patients of p53 positive, Ki-67 were high expression in 10 specimens in 40 specimens of DLBCL patients of p53 negative. The p53 expression was found significant association with Ki-67 expression. Conclusion The high expression of p53 and Ki-67 were related to non-GCB immunology type of DLBCL, The low expression of p53 and Ki-67 were related to GCB immunology type of DLBCL.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2007年第12期914-916,986,共4页
Cancer Research on Prevention and Treatment
