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低恶度甲状腺癌患者术后^(131)Ⅰ治疗 被引量:3

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摘要 有研究认为,术后第1次随访时对甲状腺球蛋白水平升高的低恶度甲状腺癌患者需进行重复131I治疗。在接受甲状腺全切除术和131I治疗的407例甲状腺癌患者中,根据12例Ⅰ期甲状腺癌患者血液中的甲状腺球蛋白的水平给予1~4个疗程3.7GBq的131I治疗。研究结果显示,3名患者的131I扫描为阴性,在治疗过程中没有任何不良反映;2名患者甲状腺床仅有轻微131I摄取,但超声检查阴性;4名患者仅在纵膈区域有131I摄取,但是随后补充的纵膈扫描没有发现异常情况,这一现象被解释为胸腺的良性131I摄取;最后3名患者既有纵膈胸腺摄取,也有轻微的甲状腺床摄取。1名患者的甲状腺球蛋白持续增长并且接受了颈部无功能淋巴结切除术。其他患者的甲状腺球蛋白水平下降。研究认为,在给一组年轻的低恶度甲状腺癌术后甲状腺球蛋白水平增高的患者131I治疗中没有发现远期损害。但当盲目的131I治疗显示甲状腺组织不摄取或仅胸腺摄取131I时,患者不应再被给予131I治疗。研究者讨论了一个假设:活性增强的胸腺也许是良性甲状腺球蛋白分泌的一个来源。
作者 韩兴 朱本章
出处 《国外医学(医学地理分册)》 CAS 2007年第4期174-176,共3页 Foreign Medical Sciences:Section of Medgeography
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