摘要
骨关节炎是以关节软骨的退行性改变为特征的非炎症性疾病。其病因及发病机制尚未完全明确,可能是由于机械力分布失衡或负荷过度引起软骨磨损,或者由于其他理化因素使软骨细胞代谢异常。损伤的细胞释放多种降解酶类,使蛋白聚糖降解,胶原蛋白网络断裂,最终导致软骨失去均一性,出现病理改变。整合素作为细胞表面受体,主要介导细胞与细胞及其与细胞外基质间的粘附及跨膜的信号转导。研究显示,整合素介导的软骨细胞与其周围基质的互相作用对细胞的生长分化有重要的作用。现就整合素与软骨细胞代谢的关系以及整合素对软骨细胞在物理环境发生变化时的作用作一综述。
Osteoarthritis is a kind of degeneration and non- inflammatory disease in joints and articular cartilage. The etiology and pathogenesis is not very clear, may be due to excessive mechanical load or unbalanced distribution of cartilage wear,and then chondrocyte metabolic changes. Cell release a variety of catabolic enzymes that lead to aggrecan degradation,collagen network use- less and cartilage unhomogeneity. Integrin is transmembrance glycoprotein and related to cells and extracellular matrix （ECM） combining, cell adhering. The review demonstrates action of integrin to cartilage metabolism and changes of chondrocyte in the different physical environment.
出处
《国外医学（医学地理分册）》
CAS
2007年第4期145-148,155,共5页
Foreign Medical Sciences：Section of Medgeography
基金
国家自然科学基金(30471499)
关键词
整合素
信号转导
骨关节炎
integrin
signal transduction
osteoarthritis
