摘要
目的:研究血管内皮生长因子C及受体3(VEGF-C、VEGFR-3)在腮腺癌中的表达及其与淋巴结转移的关系。方法:采用免疫组织化学SP法检测62例腮腺癌标本组织中VEGF-C、VEGFR-3的表达,并计算其阳性表达率。结果:VEGF-C、VEGFR-3在腮腺癌中显著表达,其阳性率分别是51.6%、48.4%,与淋巴结转移密切相关。结论:VEGF-C、VEGFR-3与淋巴结转移有相关性,为肿瘤细胞淋巴道转移提供了条件,可以作为判断腮腺癌患者预后的一个重要指标。
Objective： To study the expressions of vascular endothelial growth factor C （VEGFR-C） and vascular endothelial growth factor receptor 3 （VEGFR-3） as well as the relationship with lymph node metastasis in carcinoma of parotid gland. Methods： The expression of VEGF-C and VEGFR-3 in 62 cases with carcinoma of parotid gland was studied by the method of immunohistochemistry SP. Positive rates of expression were calculated. Results： Both VEGF-C and VEGFR-3 expressed significantly,in which the positive rates were 51.6% and 48.4% respectively,and were closely correlated with lymph node metastasis. Conclusion： There is a correlation between VEGF-C, VEGFR-3 expression and lymph node metastasis in carcinoma of parotid gland. At the same time, VEGF-C and VEGFR-3 contributed to tumour cell via lymphangiogenesis and could be an important index for the prognosis of patient with carcinoma of parotid gland.
出处
《解剖学杂志》
CAS
CSCD
北大核心
2007年第6期741-744,共4页
Chinese Journal of Anatomy
关键词
腮腺癌
血管内皮生长因子C
血管内皮生长因子受体3
淋巴结转移
carcinoma of parotid gland
vascular endothelial growth factor C
vascular endothelial growth factor receptor 3
lymph node metastasis
