摘要
从１９８２年６月开始至１９９４年末对邹城市３个乡镇２９个村的２０岁以上男女村民５８０３人进行前瞻性定群观察吸烟、饮酒与死亡的动态情况。结果表明，男女吸烟者死亡率为３７．１３／１０万人年，不吸烟者为１２．３８／１０万人年，ＲＲ＝３．０，９５％ＣＩ为１．５１～５．９５（χ２＝１０．９０，Ｐ＝０．０００９６），ＡＲ＝３．３４／１０万人年，ＡＲ％＝６６．６６％，ＰＡＲ＝３．３４／１０万，ＰＡＲ％＝２１．２５％。每日吸烟量、吸烟年限与肺癌死亡间存在明显的剂量效应关系（Ｐ＜０．００１）。每日吸烟４０支以上者的ＲＲ值是不吸烟者的７．９１倍，吸烟４０年以上者的ＲＲ值是不吸烟者的５．２５～７．６７倍。而饮酒与肺癌的死亡无联系（Ｐ＞０．０５）。吸烟与饮酒无协同致肺癌作用。
In order to investigate the association between the death of lung cancer(DLC) and smoking and drinking,a 12.5 year prospective cohort study was carried out in rural area of Zoucheng city.In June 1982,29 villages from 3 townships were randomly sampled and 15803 male and female adult villagers(aged 20 or more)were studied.A individual case card was created for each of them,their smoking and drinking habit was recorded and the data concerning their death and change were collected every year.The results of the study was as follows,the missing rate was 1.60%,the mortality of smokers of both sexes was 37.13/100000 person year while it was 12.38/100000 person year for those nonsmokers,the RR was 3.0,95% CI:1.51～5.95(χ 2=10.90,P=0.00096),AR was 24.75/100000 person year,AR% was 66.66%,PAR was 3.34/100000 person year,PAR% was 21.21%.Significant differences of dose response relationship were observed between smoking“dosage”(the number of cigarettes smoked per day),the smoking duration and the DLC.The RR of those smokers with smoking duration more than 40 years was 5.25～7.67 times as high as those under 30 years.No significant association was fund between drinking and the DLC(P>0.05) and no synergic effect of combined drinking and smoking to increase DLC was found,either.
