摘要
中药配合物新药是中药新药研制的新思路。本文通过正交实验和单因素实验研究了溶剂、温度、pH值对甘草酸与铬(Ⅲ)离子配位的影响,并利用红外光谱研究反应物的比例对配位反应的影响。结果表明,最佳的配合反应条件是pH 5.0、乙醇浓度10%(v/v)和温度30℃;反应物比例不同,所得配合物的红外光谱基本一致。
The new strategy to develop new drugs in Chinese traditional medicine is to find the active complex. To investigate the coordination reaction of glycyrrhizic acid with Cr^3＋ ,orthogonal tests and FT-IR methods are used to study the affection factors including solvent,temperature ,pH value,and the ratio of glycyrrhizic acid to Cr^3＋. The results show that the optimum processing conditions for the complex of glycyrrhizic acid and Cr^3＋ are as follows：pH =5,10% （v/v） ethanol solvent at 30 ℃. Mol ratio of glycyrrhizic acid to Cr^3＋ has no significant influence on the formation of the complex.
出处
《天然产物研究与开发》
CAS
CSCD
2007年第5期854-857,共4页
Natural Product Research and Development
基金
广州市科技计划项目(2003J1-C0011)
华南理工大学科研启动基金(D6060040)
关键词
甘草酸
铬(Ⅲ)
配位反应
glycyrrhizic acid
Cr^3＋
coordination reaction
