摘要
目的:通过对四物汤及其治疗痛经加减方的水提液及醇沉上清液对痛经模型小鼠的干预作用的对比研究,探讨四物汤及其加减方的配伍规律及物质基础。方法:利用痛经模型小鼠,观察药物对小鼠40 min内扭体次数、扭体发生率的影响。结果:各方水提液的作用强度依次为芩连四物汤>少腹逐瘀汤>香附四物汤>桃红四物汤>四物汤,但各方间无显著性差异;各方醇沉上清液的作用强度依次为少腹逐瘀汤>香附四物汤>芩连四物汤>桃红四物汤>四物汤,但各方间无显著性差异;各方水提液的作用稍强于其醇沉上清液,但各方两种提取物间均无显著性差异。结论:在四物汤基本方的基础上加减化裁后所得四物汤加减方的作用较基本方均有不同程度的提高。各方醇沉上清液较好地保留了治疗痛经的活性物质。
Abstract Objective：To study on the compatibility rules and material foundation of Siwu Decoction and its serial decoctions. Methods： Investigate the effects of the water extracts and ethanol supernatant in dysmenorrhea mice model. Results： The potencies of these water extracts were as follow： Qinlian Siwu Decoction 〉 Shaofu Zhuyu Decoction 〉 Xiangfu Siwu Decoction 〉 Taohong Siwu Decoction 〉 Siwu Decoction, while no significant difference was observed between them. The potencies of their ethanol supernatant were ： Shaofu Zhuyu Decoction 〉 Xiangfu Siwu Decoction 〉 Qinlian Siwu Decoction 〉 Taohong Siwu Decoction 〉 Siwu Decoction; no significant difference was found between them either. The effects of water extracts were slightly better than that of the ethanol supernatant. Conclusion： The effects of Siwu Decoction serial decoctions were superior to that of Siwu Decoction in different extents. The active compounds on dysmenorrhea were preserved well in their ethanol supernatant.
出处
《药学与临床研究》
2007年第6期459-461,共3页
Pharmaceutical and Clinical Research
基金
江苏省高校自然科学重大基础研究项目(编号:06KJA36022)
关键词
四物汤
加减方
痛经
配伍规律
Siwu Decoction
Modification of Prescription
Dysmenorrhea
Compatibility
