摘要
纤溶酶原激活物抑制剂1(PAI-1)是一种单链糖蛋白,起抑制纤溶活性的作用。2型糖尿病患者由于高血糖、脂代谢异常、胰岛素抵抗等因素,血浆PAI-1水平升高,纤溶活性下降,易致大血管病变,故降低血浆PAI-1水平可作为防治2型糖尿病及大血管病变的研究方向。文章通过对纤溶酶原激活物抑制剂1的基因、来源、调节因素等多方面加以综述。
Plasminogen activator inhibitor-1 （PAl-I） is a single strand glycoprotein,which can in- hibit plasminogen activation. Because of many factors including hyperglucosemia, abnormal lipid rne- tabolism,insulin resistance and so on,Patients with type 2 diabetes had increased level of plasma PAl-1 and decreased activity of fibmlysis, which will result in macroangiopathy. So,decreasing the level of PAI- l can be considered as the study direction in preventing type 2 diabetes and its macroangiopathy.This arti- cle reviews PAl-1 about its gene. souree.reaulatortv factors and so on.
出处
《医学综述》
2007年第24期1972-1973,共2页
Medical Recapitulate
基金
河北省卫生厅基金资助项目(04058)
