摘要
目的:探讨扶正养阴方对高强度聚焦超声治疗兔肝VX2肿瘤的减毒增效作用。方法:30只兔肝VX2肿瘤模型随机分为HIFU组(HIFU照射)、联用组(HIFU+扶正养阴方治疗)、对照组(不予任何治疗),每组各10只。治疗后观察1个月动物的体温,体重及肿瘤的生长、转移情况,并检测动物的体液免疫球蛋白和肝功能(ALT)。结果:联用组和HIFU组的体温、ALT均低于对照组,并且肿瘤体积较对照组缩小,比较有显著性差异。HIFU组与联用组术后免疫球蛋白有不同程度升高,对照组则呈下降趋势。术后1个月解剖全部动物,对照组全部发生肺转移,HIFU组有2只肺转移,联用组未发生转移情况。结论:扶正养阴方联用HIFU能有效地抑制兔肝VX2肿瘤的生长,减轻HIFU术后引起的发热和肝损害等不良反应,提高机体免疫力。扶正养阴方对HIFU治疗兔肝VX2肿瘤具有减毒增效的作用。
Objective： To investigate the toxicity attenuation and efficacy potentiation effects of Fu Zheng Yang Yin Decoction with HIFU on the experimental model of VX2 liver cancer in rabbits.Methods： The rabbits were all transplanted with VX2 cancer on livers.The 30 rabbits were divided into three groups： HIFU group（HIFU therapy）,Combination group（HIFU＋Fu Zheng Yang Yin decoction）,Control group（without any treatment）.Each group involved 10 rabbits.After treatment,the volume of the tumor was observed by sonography.Metastases,pathological changes,Immunoglobulin,ALT were also observed.Results： After treatment,ALT and temperature of Combination group and HIFU group were lower than Control group（P〈0.05）.The tumor volume of Combination group and HIFU group showed significant difference with control group（P〈0.05）.Immunoglobulin of HIFU group and Combination group increased,that of Control group decreased.One month after treatment,all animals were dissected.Combination group had no lung transferred,HIFU group had 2 lung transferred,all of control group had lung transferred.Conclusion： The combination therapy of Fu Zheng Yang Yin decoction with HIFU can effectively inhibited VX2 cancer growth in rabbit′s liver.Fu Zheng Yang Yin decoction can reduce side-effect,improve immune function,and has special effects of toxicity attenuation and efficacy potentiation.
出处
《中药材》
CAS
CSCD
北大核心
2007年第11期1425-1429,共5页
Journal of Chinese Medicinal Materials
基金
广东省中医药管理局资助项目(编号:401019)
关键词
高强度聚焦超声(HIFU)
VX2肿瘤
中西医结合治疗
High intensity focused ultrasound（HIFU）
VX2 tumor
Combination of Chinese traditional and western medicine
