摘要
目的探讨应用全反式维甲酸（ATRA）联合三氧化二砷（ATO）治疗初治急性早幼粒细胞白血病（APL）的疗效和毒副作用。方法初治APL57例，均接受ATRA联合ATO方案治疗。观察疗效和毒副作用。结果57例患者完全缓解（CR）54例，部分缓解（PR）2例，未缓解（NR）1例。CR率94．74％，达到CR时间22—41d。平均29．2d。结论应用ATRA联合ATO治疗初治APL有效且安全。
Objective To evaluate the efficacy and adverse effects of all- trans retinoic acid（ATRA） and arsenic trioxide （ATO） in the treatment of newly diagnosed acute promyelocytic leukemia （APL）. Methods 57 patients were treated with ATRA combined with ATO, then observed the efficacy and adverse effects. Results 54 patients reached CR, 2 PR and 1 NR . CR rate was 94.74 % . The time of achieving complete remission by ATRA combined with ArID was 22 ~ 41 days and median time to achieve CR was on 29.2 days. Conclusion ATRA and ATO in the treatment of APL was effective and well tolerated.
出处
《黑龙江医学》
2007年第12期926-927,共2页
Heilongjiang Medical Journal
