摘要
目的:探讨了消化性溃疡患者治疗前后血清胃泌素(Gas)、转化生长因子-α(TGF-α)和IL-8水平的变化及意义。方法:应用放射免疫分析和ELISA对56例消化性溃疡患者进行了治疗前后血清Gas、TGF-α和IL-8检测,并与35名正常健康人作比较。结果:消化性溃疡患者在治疗前血清Gas、IL-8水平均非常显著地高于正常人水平(P<0.01)而TGF-α水平则低于正常人(P<0.01)。治疗三个月后则与正常人比较无显著性差异(P>0.05)。结论:检测消化性溃疡患者血清中Gas、TGF-α和IL-8水平的变化可作为病情及预后评估的重要指标。
Objective To explore the clinical significance of changes of serum Gas, TGF - α and IL - 8 levels in patients with peptic ulcer. Methods Serum Gas, TGF - α （ with RIA）, IL - 8 （ with ELISA） levels were determined in 56 patients with peptic ulcer both before and after treatment as well as in 35 controls. Results Before treatment the serum Gas and IL - 8 levels were significantly higher than those in controls （ P 〈 0. 01 ） while the serum TGF - α levels were significantly lower （ P 〈 0.01 ）. After treament for 3 months the levels in patients were not much different from those in controls （ P 〉 0. 05 ）. Conclusion Serum Gas, TGF - α and IL - 8 levels were closely related to the diseases process of peptic ulcer and were of prognostic values.
出处
《放射免疫学杂志》
CAS
2007年第6期527-528,共2页
Journal of Radioimmanology
关键词
消化性溃疡
胃泌素
转化生长因子-Α
白细胞介素-8
peptic ulcer, gastfin （Gas）, transforming growth factor-alpha （TGF -α）, interleukin -8（IL-8）
