摘要
目的观察苦参素对慢性乙型肝炎患者肝纤维化指标的影响。方法60例慢性乙型肝炎患者随机分为治疗组(一般保肝治疗+苦参素)和对照组(一般保肝治疗),治疗前后检测肝功能,用放射免疫法检测血清肝纤维化指标透明质酸(HA)、层黏蛋白(LN)、Ⅲ型前胶原(PC-Ⅲ)和Ⅳ型胶原(CⅣ)。结果治疗组治疗后HA、LN、PC-Ⅲ和CⅣ水平较治疗前及对照组治疗后均显著降低(P<0.05或P<0.01)。结论苦参素是能降低肝纤维化指标,有一定的抗肝纤维化作用。
Objective To study the effect of kwoninone on liver fibrosis indices in patients with chronic hepatitis B. Methods Sixty patients were randomly divided into treatment group （30 cases with kwoninone ） and control group （30 cases with conventional treatment）. Serum levels of precollagen type Ⅲ, Ⅳ - type collagen, hyaluronic acid （HA） and laminin （ LN ） were measured by RIA before and after treatment. Results After treatment, Serum levels of precollagen type Ⅲ, Ⅳ - type collagen, hyaluronic acid （HA） and laminin （ LN ） in kwoninone treatment group decreased significantly, while there was no difference among those of control group before and after treatment. Conclusion The levels of cytokines in patients with CHB can be decreased by treatment of kwoninone which has certain anti - fibrotic effect on liver fibrosis.
出处
《临床和实验医学杂志》
2007年第12期42-43,共2页
Journal of Clinical and Experimental Medicine
关键词
苦参素
肝纤维化
乙肝病毒标志物
Kwoninone
Livet fibrosis
Hepatitis B virus markers
