摘要
Protein adsorption behavior on the surfaces of biomedical materials is highly related to the biocom- patibility of the materials. In the past, numerous research reports were mainly focused on the effect of chemical components of a material’s surface on protein adsorption. The effect of surface topography on protein adsorption, the topic of this review, has recently received keen interest. The influence of surface nano-topographic factors, including roughness, curvature and geometry, on protein adsorption as well as the protein adsorption behavior, such as the amount of protein adsorbed, the activity and morphology of adsorbed protein, is introduced.
Protein adsorption behavior on the surfaces of biomedical materials is highly related to the biocompatibility of the materials. In the past, numerous research reports were mainly focused on the effect of chemical components of a material＇s surface on protein adsorption. The effect of surface topography on protein adsorption, the topic of this review, has recently received keen interest. The influence of surface nano-topographic factors, including roughness, curvature and geometry, on protein adsorption as well as the protein adsorption behavior, such as the amount of protein adsorbed, the activity and morphology of adsorbed protein, is introduced.
基金
Supported by the National Natural Science Foundation of China (Grant Nos. 90606013 and 20634030)
the Ministry of Science and Technology (Grant No. 107080)
关键词
蛋白质
吸附
材料表面
地形图
生物适应性
nano-topography, protein adsorption, biocompatibility, materials surfaces
