摘要
药物流行病学研究已进一步证实华人患者对华法令的抗凝作用较为敏感.维持剂量的决定因素是患者的年龄而不是体重.维持一个2.0～2.5的INR(国际标准化比值)的平均剂量为3mg/d.推荐的首二日标准“负荷”剂量为5mg.如何用第3、第4日的INR预测维持剂量需评估.大出血的发生率及论断性因素亦需在以后的研究中确定.
Pharmaco-epidemiological studies have confirmed that Chinese patients are more sensitive to the anticoagulant effect of warfarin. The age of the patient rather than the body weight is the most important determinant of the maintenance dose. The mean dose required to maintain an INR of 2.0~2.5 is around 3 mg/day. It has been recommended that the standard 'loading' dose for the first two days should be 5 mg. How the INR on day 3 and day 4 can be used to predict the maintenance dose needs to be evaluated. The incidence of major bleeding and the predictive factors also need to be determined in future studies.
出处
《药物流行病学杂志》
CAS
1997年第3期134-135,共2页
Chinese Journal of Pharmacoepidemiology
