摘要
真核生物的基因组由基因和基因间区组成.基因转录时,从转录起始点开始到该基因的转录终止点结束,形成独立的转录单元.然而有少量的文献表明,转录有时会通读基因间区,产生包含上游基因、基因间区和下游基因的融合基因转录本.融合转录本经基因间剪接而成为有功能的成熟转录本.对真核生物转录诱导融合基因的基因间剪接方式、产生机制和意义进行了综述.
Eukaryotic genomes are composed of individual genes and their intergenic regions. Traditionally, it has been held that the transcription of a gene always begins from the transcription start site and ends at the termination site, the gene is referred as an individual transcription unit. However, some sporadic studies indicate that transcription can sometimes read-through the intergenic region and generates a large fusion transcript which contains the upstream gene, intergenic region and the downstream adjacent gene. The fusion transcript becomes a mature functional transcript after intergenic splicing. The patterns of intergenic splicing, possible generation mechanism and its significance are summarized.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2007年第12期1255-1259,共5页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金重点项目(60433020)
教育部重点项目(02090)~~
关键词
基因间区
转录
融合转录本
intergenic region, transcription, fusion transcript
